Hyaluronic acid was first isolated and described in 1934 from the vitreous body of a cow’s eye. The first in vitro synthesis was conducted in 1964. The name “hyaluronan” originates from the Greek word “hyalos,” meaning “glass,” and refers to its transparent, glass-like appearance. This article will answer common questions such as “What is hyaluronic acid?” and explore its properties and effects. Let’s dive in!

What Is Hyaluronic Acid?

Hyaluronic acid (HA) belongs to a group of compounds known as glycosaminoglycans (GAGs), which are large molecules composed of repeating sugar units. It consists of two types of sugars: D-glucuronic acid and N-acetylglucosamine, which are connected in a specific manner.

Hyaluronic acid is a component of the extracellular matrix, meaning it is found in the space between cells as well as in tissues such as skin, cartilage, joints, and eyes. Its ability to bind large amounts of water makes it a key factor in maintaining hydration and elasticity in tissues.

It is a natural compound with the same chemical structure in humans, other vertebrates, and some bacteria. In living organisms, hyaluronic acid primarily exists as a sodium salt, known as sodium hyaluronate.

An average adult human body contains about 15 grams of hyaluronic acid, with half of it located in the skin.

What Is Hyaluronic Acid Good For?

As we know, hyaluronic acid is a naturally occurring substance in our bodies. Here are its key properties:

  • Hydrating properties: Hyaluronic acid is renowned for its ability to bind water, making it an effective moisturiser for the skin.
  • Tissue regeneration: It plays a crucial role in wound healing and tissue regeneration.
  • Anti-inflammatory effects: Hyaluronic acid has anti-inflammatory properties, making it useful in treating inflammatory conditions.
  • Joint protection: It is an essential component of synovial fluid, acting as a lubricant and cushion in the joints, reducing pain and improving function in joint-related conditions.
  • Nutrient transportation: Hyaluronic acid supports the transport of nutrients to cells, positively affecting overall tissue health.

Due to these properties, hyaluronic acid is widely used in cosmetics, aesthetic medicine procedures (e.g., fillers), and orthopaedic treatments. Its natural origin makes it generally well-tolerated by the body.
Hyaluronic acid supplements, which have become a new trend, are worth considering. They can support skin hydration from within and improve joint elasticity, offering additional health and beauty benefits.

What Does Hyaluronic Acid Do?

Hyaluronic acid is an incredibly versatile compound that plays a key role in many biological processes in the body. Its unique properties make it not only a staple ingredient in numerous cosmetic products but also the subject of extensive scientific research on supplementation. So, what does hyaluronic acid help with? Below are its main benefits for the body.

Skin Hydration and Wrinkle Reduction — Study by Asserin et al. (2015)
In this study, participants took oral hyaluronic acid supplements for 12 weeks at a dose of 120 mg per day. The aim was to improve skin hydration and elasticity. After 12 weeks, significant improvements in skin hydration and elasticity were observed, suggesting that regular use of HA has a positive impact on skin health. Additionally, improved elasticity and firmness can reduce the visibility of wrinkles.

Joint Health — Study by Kalman et al. (2008)
This study investigated the use of hyaluronic acid supplements for relieving joint pain. Participants took 80 mg of hyaluronic acid daily for four weeks. Results suggested reduced joint pain and improved joint function, indicating the benefits of short-term hyaluronic acid supplementation for joint issues.

Tissue Regeneration and Wound Healing — Study by Litwiniuk et al. (2016)
This research examined the effects of hyaluronic acid on tissue regeneration, particularly in wound healing. Hyaluronic acid supplementation lasted from 3 to 6 months, applied either topically or orally, depending on the condition. The duration varied based on the type and location of skin damage and therapeutic goals.

Eye Protection (Dry Eye Syndrome)
Studies such as “Oral hyaluronic acid supplementation improves symptoms and tear film stability in dry eye patients” confirmed that oral hyaluronic acid provides relief for individuals suffering from dry eyes.

Further research into hyaluronic acid continues to explore its potential applications and mechanisms of action. As science advances, we can expect new discoveries that will positively impact our health and well-being.

How to Use Hyaluronic Acid

Hyaluronic acid is a popular ingredient in dietary supplements and cosmetics, valued for its hydrating properties and support for joint health. To maximise its benefits, it’s essential to understand the recommended dosages and forms. Here’s how to use hyaluronic acid:

Recommended Dosages:
The most commonly recommended doses of hyaluronic acid in supplements range from 100 to 250 mg per day. However, always check the manufacturer’s guidelines before starting supplementation.

Supplement Forms:
Hyaluronic acid is available in various forms, including capsules, tablets, powders, and liquid solutions. The choice of form depends on personal preference.

Timing:
Hyaluronic acid supplements can be taken with or without food. However, some studies suggest that taking them with meals may improve absorption.

Is Hyaluronic Acid Safe?

Hyaluronic acid supplementation is generally considered safe for most people. However, like any supplement, it may cause side effects or interactions in some individuals. While there is growing evidence of its benefits, individual reactions can vary.

Can You Use Hyaluronic Acid With Vitamin C?

How to use hyaluronic acid? Can it be combined with vitamin C? Absolutely! Both ingredients offer potential health benefits. Moreover, combining hyaluronic acid and vitamin C can enhance skin hydration and overall well-being. Additionally, hyaluronic acid and vitamin C may act synergistically. Vitamin C supports collagen synthesis, and research suggests that hyaluronic acid is also crucial in this process.

Hyaluronic acid may also stimulate collagen production in joints. Studies on osteoporosis involving oral hyaluronic acid supplementation have shown improvements in collagen production in cartilage tissues. According to a 2015 study published in Osteoarthritis and Cartilage, hyaluronic acid can stimulate chondrocytes (cartilage cells) to produce collagen and proteoglycans, aiding cartilage regeneration.

To get the best results, it’s advisable to combine hyaluronic acid with vitamin C and collagen, which supports absorption and promotes skin and joint health.

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